eMultiple Sclerosis Review

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Arun Venkatesan, MD PhD
Associate Professor, Neurology
Director, Johns Hopkins Encephalitis Center
Associate Program Director, Neurology Residency
Johns Hopkins University School of Medicine
Baltimore, Maryland

Dr. Arun Venkatesan specializes in immunological/inflammatory and infectious diseases that affect the nervous system. Examples include multiple sclerosis, sarcoidosis, transverse myelitis, central nervous system lupus, CNS vasculitis, viral encephalitis, Creutzfeld Jakob Disease, neurologic complications of HIV/AIDS, and paraneoplastic conditions.

Dr. Venkatesans laboratory seeks to: 1) to determine how to protect axons, which are the cables that connect neurons to each other, from inflammatory or infectious damage; and 2) to understand mechanisms by which new neurons can replace damaged cells within the brain and spinal cord. Dr. Venkatesan anticipates that this research will have applications toward a number of diseases, including multiple sclerosis and viral infections of the nervous system.

Dr. Arun Venkatesan received his Ph.D. in microbiology/immunology and his M.D. from the University of California, Los Angeles, followed by an internship in internal medicine at Santa Clara Valley Medical Center. He completed his residency in neurology at The Johns Hopkins Hospital.

Arun Venkatesan, MD, PhD discloses that he has served as a consultant for MedImmune.

Scott Douglas Newsome, DO
Assistant Professor of Neurology
Director, Neurology Outpatient Services
Director, Neurology Infusion Center
Johns Hopkins University School of Medicine
Baltimore, Maryland

Dr. Scott Newsome specializes in the care of patients with neuroimmunological and neuroinflammatory disorders of the central nervous system. He has special interest in evaluating and treating patients with multiple sclerosis, transverse myelitis, neuromyelitis optica, and stiff person syndrome. His research focuses on the use of new quantitative clinical outcome measures and imaging techniques in multiple sclerosis. These tools may improve the precision of disability measurements in multiple sclerosis and other central nervous system disorders. Dr. Newsome is also interested in developing a research program to better understand the pathobiology of stiff person syndrome which may help identify better treatments for this very rare condition. Currently, Dr. Newsome is involved in several clinical trials for multiple sclerosis, transverse myelitis, and neuromyelitis optica.

Dr. Newsome received his medical degree from the New York College of Osteopathic Medicine (NYCOM) and graduated with honors. He then completed his internship in internal medicine and residency in neurology at Albany Medical Center. During Dr. Newsomes neurology residency, he was awarded the Golden Apple Outstanding Resident Teaching Award and later was chosen to be chief resident. He subsequently went on to complete a fellowship in neuroimmunology at The Johns Hopkins Hospital with the support of a Sylvia Lawry Physician Fellowship from the National Multiple Sclerosis Society.

Scott Douglas Newsome, DO discloses that he has served as a consultant for Biogen Idec, Genzyme, and Novartis. He has received grant/research funding from Biogen Idec and Novartis.

Volume 1

Accreditation Statement

Physicians

The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designations

Physicians

eNewsletter: The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Podcast: The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Course Format

The eMultipleSclerosis Review series will consist of a monthly review of journal literature on key, pertinent topics, emailed as either a newsletter or podcast, to clinicians caring for patients with multiple sclerosis. The timely commentary on current research, best practices and clinical management issues is provided by an expert panel of multiple sclerosis specialists. The activities are delivered as 3 bi-monthly newsletters and 3 alternating podcasts. Participants will have up to 2 years to complete the 3 newsletters and 3 podcasts in order to earn CME credit.

Date of release: June 30, 2015
Expiration date: November 18, 2017

Estimated time to complete each activity: 60 minutes per newsletter, 30 minutes per podcast

Statement of Responsibility

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

Intended Audience

The target audience (clinicians) for this initiative includes neurologists, physician assistants, and other healthcare providers who care for patients with MS.

Learning Objectives

After participating in this activity, the participant will demonstrate the ability to:

Explain the factors involved in developing personalized DMT regimens based on patients’ disease progression and tolerability to specific treatment options.
Describe how to best explain the risks of medication non-adherence to patients with MS.
Identify specific modifiable lifestyle factors that may influence the progression of MS and how to communicate them to patients.
Describe the advantages of monitoring disease progression and treatment efficacy through newer MRI techniques.
Evaluate the impact of proactive management of MS physical and cognitive symptoms on patient QOL.

Launch Date

June 30, 2015; activities expire two years from the date of the publication.

Planners Disclosures

As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. The following relationships have been reported for this activity:

Arun Venkatesan, MD, PhD discloses that he has served as a consultant for MedImmune.

Scott Douglas Newsome, DO discloses that he has served as a consultant for Biogen Idec, Genzyme, and Novartis. He has received grant/research funding from Biogen Idec and Novartis.

Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

Statement of Need

Clinician inability to recognize the efficacy of Disease-Modifying Therapies (DMTs) at various stages of the disease limits patients receiving the full clinical and QOL benefits of new treatments.
Clinicians are not effectively informing patients about how adherence to MS treatment may reduce adverse events (AEs).
Clinicians fail to convincingly communicate the importance of modifiable lifestyle choices that can exacerbate MS.
Clinicians are not optimally using MRI to monitor both disease progression and treatment plan efficacy.
Clinicians are not sufficiently aware of the importance and benefit of symptom management to the QOL of MS patients.

Disclaimer Statement

The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of the Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings, and adverse effects before administering pharmacologic therapy to patients.

Successful Completion

To take the post-test for eMultipleSclerosis Review you will need to visit the Johns Hopkins University School of Medicine's CME. If you have already registered for other Hopkins CE programs at these sites, simply enter the requested information when prompted. Otherwise, complete the registration form to begin the testing process. A passing grade of 70% or higher on the post-test/evaluation is required to receive CE credit.

There are no fees or prerequisites for this activity.

This activity is supported by educational grants from Mallinckrodt Pharmaceuticals and Novartis Pharmaceuticals Corporation.

Confidentiality Disclaimer for CME Activity Participants

I certify that I am participating in a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am participating in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the Privacy Regulations). Protected health information is information about a person's health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos on any social medial site (e.g. Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.

"The Office of Continuing Medical Education at The Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only."

For CME questions, please contact the CME Office (410) 955-2959 or e-mail cmenet@jhmi.edu. For certificates, please call (410) 502-9634.

Johns Hopkins University School of Medicine Office of Continuing Medical Education
Turner 20/720
Rutland Avenue
Baltimore, Maryland 21205-2195

Reviewed & Approved by:
General Counsel, Johns Hopkins Medicine (4/1/03)
(Updated 4/09 and 3/14)

Hardware & Software Requirements

To access activities, users will need:

A computer with an internet connection
An HTML compliant web browser or Internet Explorer 8 (and higher)

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eMultipleSclerosis Review

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Volume 1 – Supported by educational grants from Mallinckrodt Pharmaceuticals and Novartis Pharmaceuticals Corporation

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